In addition to David Patrick Kelly (Luther), James Remar and Sonny Landham also appear in Walter Hill's "The Warriors" (Remar plays Ajax and Landham plays a cop). "48 HRS" marks the second film that Hill, Remar, Kelly and Landham are involved in.
Eddie Murphy met music producer Narada Michael Walden when the Church Street Station scene was filmed. The scene was shot right under Walden's former office on the corner of Church and Market. Walden would later write and produce Murphy's album 'So Happy' in 1989 with the hit song 'Put Your Mouth on Me'.
The Jack Cates character would later serve as inspiration when creating the Sonny Crockett character on Miami Vice. Ironically, Olivia Brown, who plays Eddie's girlfriend near the end of the film, went on as a regular on that show.