Dudley Moore won a Golden Globe as Best Actor in a Musical or Comedy for his performance as Rob Salinger.
Amy Irving's real-life mother, actress Priscilla Pointer, often appears in Irving's films, usually playing the mother of Irving's character. In this film, Pointer is playing the mother of Ann Reinking's character.
This was Ann Reinking's fourth and final film. Prior to "Micki & Maude" she had appeared in "Movie Movie" (1978), "All That Jazz" (1979) and "Annie" (1982).